Solidot
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科学家在老鼠身上长出人类肝脏
http://solidot.org.feedsportal.com/c/33236/f/556826/s/2e3d1a77/l/0L0Ssolidot0Borg0Cstory0Dsid0F35463/story01.htm
Jul 5th 2013, 08:53
根据发表在《自然》上的论文,日本和美国科学家合作,利用人类诱导多能干细胞(iPS细胞)构建出微小"肝芽",然后移植到小鼠体内,这些肝芽成功生长成微型人类肝脏,并像健康器官一样具有正常的肝功能。研究人员表示,这是首次报告从iPS细胞培育出功能性人类器官,虽然还只是初步成果,但却有望给再生医学领域带来革新性的疗法,减少对于捐赠器官的依赖。研究显示,这些直径约4毫米至5毫米的肝芽在肝功能衰竭的小鼠体内存活下来,并"接手"了肝脏的正常工作——分泌肝特异性蛋白、清除血液中的毒素、产生人类特异性代谢物。移植后的肝芽很快就与附近的血管融合,获得了受体血液系统的支持,从而得以持续生长。This entry passed through the Full-Text RSS service — if this is your content and you're reading it on someone else's site, please read the FAQ at fivefilters.org/content-only/faq.php#publishers. Five Filters recommends: 'You Say What You Like, Because They Like What You Say' - http://www.medialens.org/index.php/alerts/alert-archive/alerts-2013/731-you-say-what-you-like-because-they-like-what-you-say.html
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