ScienceDaily: Latest Science News
Breaking science news and articles on global warming, extrasolar planets, stem cells, bird flu, autism, nanotechnology, dinosaurs, evolution -- the latest discoveries in astronomy, anthropology, biology, chemistry, climate and environment, computers, engineering, health and medicine, math, physics, psychology, technology, and more -- from the world's leading universities and research organizations.
Feast to famine: Oxygen starvation regulates fat cells in obesity
http://feeds.sciencedaily.com/~r/sciencedaily/~3/-Ny_O3iRdnk/130925112233.htm
Sep 25th 2013, 15:22
Sep. 25, 2013 — Researchers at Kanazawa University have identified the role of the protein TIS7 in processes that regulate adipogenesis, whereby non-specialised cells become adipose or fat cells.
Studies of the effects of oxygen deprivation in the body fat of obese animals have revealed links with the regulation of fat cell generation. Researchers at Kanazawa University have identified the role of the protein TIS7 in processes that regulate adipogenesis, whereby non-specialised cells become adipose or fat cells. They add, "TIS7 could be a target for the discovery and development of a drug useful for the treatment and therapy of obesity or a variety of obesity-related metabolic diseases including type-2 diabetes and atherosclerosis."
Adipose tissue is essential for whole body homeostasis, storing excess energy and potentially a number of other physiological processes. Deregulation of these functions is found in obesity, prompting further study of the mechanisms behind white adipose tissue development.
Adipose tissue is poorly oxygenated in obese humans and animals. Poor oxygenation or 'hypoxia' has been linked to a number of diseases including heart and lung disorders, anemia, and circulation problems. There have also been reports indicating that the protein TIS7 is expressed in tissues following injuries, such as ischemia, stroke or muscle trauma. Yukio Yoneda and colleagues at the University of Kanazawa monitored TIS7 expression in vitro and found that it was drastically increased by hypoxic stress.
The researchers then compared mice fed different diets and found significant up-regulation of TIS7 in the white adipose tissue of mice fed a high fat diet. Following further studies of various aspects of adipogenesis and the role of hypoxia and TIS7, the researchers conclude, "It thus appears that TIS7 is a novel pivotal transcriptional regulator of hypoxia-induced repression of adipogenesis." They add that further studies are needed to understand the exact mechanism underlying the up-regulation of TIS7 under hypoxia in cells prior to adipogenesis.
This entry passed through the Full-Text RSS service — if this is your content and you're reading it on someone else's site, please read the FAQ at fivefilters.org/content-only/faq.php#publishers. Five Filters recommends: Massacres That Matter - Part 1 - 'Responsibility To Protect' In Egypt, Libya And SyriaMassacres That Matter - Part 2 - The Media Response On Egypt, Libya And SyriaNational demonstration: No attack on Syria - Saturday 31 August, 12 noon, Temple Place, London, UK
You are receiving this email because you subscribed to this feed at http://blogtrottr.com
If you no longer wish to receive these emails, you can unsubscribe here:
http://blogtrottr.com/unsubscribe/cz0/tSbHWJ
没有评论:
发表评论