ScienceDaily: Latest Science News: Cancer treatment could target inflammation in CVD

ScienceDaily: Latest Science News

Breaking science news and articles on global warming, extrasolar planets, stem cells, bird flu, autism, nanotechnology, dinosaurs, evolution -- the latest discoveries in astronomy, anthropology, biology, chemistry, climate and environment, computers, engineering, health and medicine, math, physics, psychology, technology, and more -- from the world's leading universities and research organizations.

Cancer treatment could target inflammation in CVD
http://feeds.sciencedaily.com/~r/sciencedaily/~3/kSFPN-PLCog/130505073744.htm
May 5th 2013, 11:37

May 5, 2013 — Peptide receptor radionuclide therapy (PRRT) with radiolabeled somatostatin analogs, an established treatment for cancer patients, could offer a novel therapeutic approach to decrease levels of inflammation in the atherosclerotic plaques of patients with cardiovascular disease (CVD), reported an abstract¹ study at the International Conference on Nuclear Cardiology and Cardiac CT, May 5 to 8 in Berlin, Germany.

"Our results should act as a stimulus for further exploration of radionuclide based interventions in atherosclerosis. Ultimately such therapies might be used to lower the degree of inflammation in atherosclerosis which has the potential to reduce the occurrence of heart attacks," said Imke Schatka, the first author of the study from the Department of Nuclear Medicine at Hannover Medical School, Germany.
PRRT is a technique currently used to treat patients with metastatic neuroendocrine tumours (NETS), a diverse group of malignancies deriving from the neuroendocrine cell system (the most frequent locations being pancreas, small intestine and lung).
The discovery of over expression of somatostatin receptors (SSTR) on NET tumours first opened the way for development of radiolabelled somatostatin analogs to image tumours during PET/CT scans. DOTATATE is a somatostatin receptor (SSTR) ligand targeting SSTR-2, a receptor known to be expressed on 70% of NET tumours. Once tumours have been visualized, it is possible to target therapy by attaching the beta-emitter ¹⁷⁷ Lutetium (¹⁷⁷Lu) to the ligand.
Active inflammation has been widely implicated in the initiation, progression and disruption of vulnerable plaques, and consequently offers an emerging target for the imaging and treatment of atherosclerosis. "Since SSTR-2 receptors are also expressed on macrophages we speculated that DOTATATE-PET/CT might be used to detect vulnerable plaques and that a PRRT procedure could reduce inflammation in the arterial wall," explained Schatka.
For the current study, 11 patients (from a group of 165 undergoing PRRT for NET tumours) were retrospectively identified because they met the criteria of only receiving the beta emitter¹⁷⁷Lu treatment after undergoing two consecutive scans, with a third scan following treatment.
For each of the three scans, vessel wall uptake of the DOTATATE ligand was measured in six arterial segments of PET images (carotid, aortic arch, ascending, descending, abdominal aorta, and iliac arteries) and then the overall vessel uptake was determined for each individual patient.
Results showed that for the first scan the overall vessel uptake of the ligand correlated with the age of the patient (P<0.01), the number of calcified plaques (P<0.001) and furthermore was higher in subjects with hypercholesterolemia (p=0.04). No significant differences in overall vessel uptakes were found between scans 1 and 2, confirming reproducibility in the absence of treatment.
However, when treatment with the beta-emitter ¹⁷⁷ Lu-DOTATATE was delivered following scan 2, scan 3 showed significant reductions in the overall vessel uptake of the ligand when compared with both scan 1 (p=0.001) and scan 2 (p=0.004).
"Uptake of the ligand can be considered to be a measure of the quantity of SSTR receptors, which in turn is likely to correlate with the number of activated macrophages and the extent of the inflammatory process," explained Schatka. "Our results suggest that treatment has had a beneficial effect in reducing inflammation."
The next step, said Schatka, would be to get histological proof that reductions in inflammation really had been imaged with DOTATATE-PET/CT by looking at carotid artery samples removed from patients during routine surgery.
Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

Story Source:

The above story is reprinted from materials provided by European Society of Cardiology, via EurekAlert!, a service of AAAS.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.





Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
This entry passed through the Full-Text RSS service — if this is your content and you're reading it on someone else's site, please read the FAQ at fivefilters.org/content-only/faq.php#publishers. Five Filters recommends: Thatcher's Tyrants - The Tanks, The Guns, The Christmas Cards.



You are receiving this email because you subscribed to this feed at http://blogtrottr.com

If you no longer wish to receive these emails, you can unsubscribe here:
http://blogtrottr.com/unsubscribe/cz0/tSbHWJ