ScienceDaily: Latest Science News: How cancer spreads: Metastatic tumor a hybrid of cancer cell and white blood cell

ScienceDaily: Latest Science News

Breaking science news and articles on global warming, extrasolar planets, stem cells, bird flu, autism, nanotechnology, dinosaurs, evolution -- the latest discoveries in astronomy, anthropology, biology, chemistry, climate and environment, computers, engineering, health and medicine, math, physics, psychology, technology, and more -- from the world's leading universities and research organizations.

How cancer spreads: Metastatic tumor a hybrid of cancer cell and white blood cell
http://feeds.sciencedaily.com/~r/sciencedaily/~3/XEeU0mPMfjc/130702141514.htm
Jul 2nd 2013, 18:15

July 2, 2013 — Yale Cancer Center scientists, together with colleagues at the Denver Police Crime Lab and the University of Colorado, have found evidence that a human metastatic tumor can arise when a leukocyte (white blood cell) and a cancer cell fuse to form a genetic hybrid. Their study, published in the journal PLOS ONE, may answer the question of how cancer cells travel from the primary tumor's site of origin to distant organs and tissues of the body -- the deadly process of metastasis.

Share This:






Such a theory was first proposed as an explanation for metastasis more than a century ago. But until now, the theory was unproven in human cancer because genomic differences between cells from the same patient cannot be distinguished. To get around this problem, the researchers analyzed genomic DNA in the secondary malignancies of a patient who had a melanoma brain metastasis and had received a bone marrow transplant from his brother.
They found signature genes from both the patient and donor together in the tumor cells, providing the first evidence that leukocytes (in this case from the donor) can fuse with cancer cells and initiate a tumor.
"Our results provide the first proof in humans of a theory, proposed in 1911 by a German pathologist, that metastasis can occur when a leukocyte and cancer cell fuse and form a genetic hybrid," said corresponding author John Pawelek, research faculty in the dermatology department of the Yale School of Medicine. "This could open the way to new therapy targets, but much work needs to be done to determine how fusion occurs, the frequency of such hybrids in human cancers, and the potential role of hybrids in metastasis," he added.
First authors are Rossitza Lazova of Yale and Greggory LaBerge of the University of Colorado and Denver Police Department Crime Lab; other authors are Vincent Klump, Mario Sznol, Dennis Cooper, and Joseph Chang of Yale; Eric Duvall of the Denver Police Crime Lab; and Nicole Spoelstra and Richard Spritz of the University of Colorado.
The study was supported by an unrestricted gift from the Amway Corporation and from the University of Colorado Cancer Center NCI Support Grant (P30CA046934).

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

Story Source:

The above story is reprinted from materials provided by Yale University. The original article was written by Helen Dodson.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:
Rossitza Lazova, Greggory S. LaBerge, Eric Duvall, Nicole Spoelstra, Vincent Klump, Mario Sznol, Dennis Cooper, Richard A. Spritz, Joseph T. Chang, John M. Pawelek. A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer. PLoS ONE, 2013; 8 (6): e66731 DOI: 10.1371/journal.pone.0066731



Note: If no author is given, the source is cited instead.

This entry passed through the Full-Text RSS service — if this is your content and you're reading it on someone else's site, please read the FAQ at fivefilters.org/content-only/faq.php#publishers. Five Filters recommends: 'You Say What You Like, Because They Like What You Say' - http://www.medialens.org/index.php/alerts/alert-archive/alerts-2013/731-you-say-what-you-like-because-they-like-what-you-say.html



You are receiving this email because you subscribed to this feed at http://blogtrottr.com

If you no longer wish to receive these emails, you can unsubscribe here:
http://blogtrottr.com/unsubscribe/cz0/tSbHWJ