ScienceDaily: Latest Science News
Breaking science news and articles on global warming, extrasolar planets, stem cells, bird flu, autism, nanotechnology, dinosaurs, evolution -- the latest discoveries in astronomy, anthropology, biology, chemistry, climate and environment, computers, engineering, health and medicine, math, physics, psychology, technology, and more -- from the world's leading universities and research organizations.
Loss of function of a single gene linked to diabetes in mice
http://feeds.sciencedaily.com/~r/sciencedaily/~3/IhYonw_hf-w/140103205137.htm
Jan 4th 2014, 01:51
Jan. 3, 2014 — Researchers from the University of Illinois at Chicago College of Medicine have found that dysfunction in a single gene in mice causes fasting hyperglycemia, one of the major symptoms of type 2 diabetes. Their findings were reported online in the journal Diabetes.
If a gene called MADD is not functioning properly, insulin is not released into the bloodstream to regulate blood sugar levels, says Bellur S. Prabhakar, professor and head of microbiology and immunology at UIC and lead author of the paper.
Type 2 diabetes affects roughly 8 percent of Americans and more than 366 million people worldwide. It can cause serious complications, including cardiovascular disease, kidney failure, loss of limbs and blindness.
In a healthy person, beta cells in the pancreas secrete the hormone insulin in response to increases in blood glucose after eating. Insulin allows glucose to enter cells where it can be used as energy, keeping glucose levels in the blood within a narrow range. People with type 2 diabetes don't produce enough insulin or are resistant to its effects. They must closely monitor their blood glucose throughout the day and, when medication fails, inject insulin.
In previous work, Prabhakar isolated several genes from human beta cells, including MADD, which is also involved in certain cancers. Small genetic variations found among thousands of human subjects revealed that a mutation in MADD was strongly associated with type 2 diabetes in Europeans and Han Chinese.
People with this mutation had high blood glucose and problems of insulin secretion -- the "hallmarks of type 2 diabetes," Prabhakar said. But it was unclear how the mutation was causing the symptoms, or whether it caused them on its own or in concert with other genes associated with type 2 diabetes.
To study the role of MADD in diabetes, Prabhakar and his colleagues developed a mouse model in which the MADD gene was deleted from the insulin-producing beta cells. All such mice had elevated blood glucose levels, which the researchers found was due to insufficient release of insulin.
"We didn't see any insulin resistance in their cells, but it was clear that the beta cells were not functioning properly," Prabhakar said. Examination of the beta cells revealed that they were packed with insulin. "The cells were producing plenty of insulin, they just weren't secreting it," he said.
The finding shows that type 2 diabetes can be directly caused by the loss of a properly functioning MADD gene alone, Prabhakar said. "Without the gene, insulin can't leave the beta cells, and blood glucose levels are chronically high."
Prabhakar now hopes to investigate the effect of a drug that allows for the secretion of insulin in MADD-deficient beta cells.
"If this drug works to reverse the deficits associated with a defective MADD gene in the beta cells of our model mice, it may have potential for treating people with this mutation who have an insulin-secretion defect and/or type 2 diabetes," he said.
Jose Oberholzer, chief of transplantation surgery, and Ajay V. Maker, assistant professor of surgery at the University of Illinois Hospital & Health Sciences System; Yong Wang, Ryan Carr, Samir Haddad, Ze Li, Lixia Qian, and Qian Wang of the UIC College of Medicine; and Liang-Cheng Li of Xiamen University are co-authors on the paper.
This research was supported by grant R01DK91526 from the National Institutes of Health.
This entry passed through the Full-Text RSS service — if this is your content and you're reading it on someone else's site, please read the FAQ at fivefilters.org/content-only/faq.php#publishers.
You are receiving this email because you subscribed to this feed at https://blogtrottr.com
If you no longer wish to receive these emails, you can unsubscribe here:
https://blogtrottr.com/unsubscribe/cz0/tSbHWJ
订阅:
博文评论 (Atom)
博客归档
-
▼
2014
(3023)
-
▼
一月
(1236)
- 科技要闻-新浪科技: 配置各不同 三星Galaxy S5型号共有18种
- 科技要闻-新浪科技: 搭载骁龙800 三星曝首款Tizen手机官方图
- 科技要闻-新浪科技: 低分辨率/联发科CPU HTC低端新机曝光
- 科技要闻-新浪科技: 中国概念股周五收盘涨跌互现 360股价破100美元
- Latest Science News -- ScienceDaily: One planet, t...
- Latest Science News -- ScienceDaily: Forensic expe...
- Latest Science News -- ScienceDaily: How neurons c...
- Solidot: 老年人的大脑不迟钝,他们只是需要时间处理信息
- Solidot: 第一家公立大学支持比特币支付学费
- 科技要闻-新浪科技: 空中网宣布将收购联众少数股权
- 科技要闻-新浪科技: 微信红包或存漏洞:泄露银行卡信息及提现记录
- Solidot: LibreOffice 4.2 发布
- Solidot: 20%的尼安德特人基因组留在现代人类基因中
- Solidot: Debian init系统投票结果是...
- Solidot: 比特币中国恢复人民币存款支付,再次成为最大交易平台
- 科技要闻-新浪科技: 打车软件暗藏隐患:诱发危险驾驶 助推黑车生意
- 网易科技频道IT业界新闻: 2013年Android手机占近80% iOS下降至15%
- 科技要闻-新浪科技: 大屏之争 酷派大神与小米3对比评测
- 科技要闻-新浪科技: 千万像素6英寸八核机 中兴Memo II评测
- 科技要闻-新浪科技: 2100万像素?疑似三星Galaxy S5摄像头样张曝光
- 科技要闻-新浪科技: 中国概念股周四收盘涨跌互现 奇虎360涨6.8%
- Latest Science News -- ScienceDaily: Cell cycle sp...
- Latest Science News -- ScienceDaily: Nearly everyo...
- Latest Science News -- ScienceDaily: Researchers d...
- Solidot: 英国政府考虑切换到开源办公软件
- Solidot: 真实的绝命毒师游荡在互联网上
- 科技要闻-新浪科技: 京东招股书概要:“最后一公里”物流仍是挑战
- 科技要闻-新浪科技: Facebook净利增7.2倍盘前暴涨18%
- 科技要闻-新浪科技: 京东股权结构:刘强东持股18.4%
- 科技要闻-新浪科技: IPO文件显示:京东融资及发展史
- Solidot: 3.7万名玩家成为论文的共同作者
- Latest Science News -- ScienceDaily: Dinosaur foss...
- Latest Science News -- ScienceDaily: Blood and lym...
- Latest Science News -- ScienceDaily: Disappearing ...
- 科技要闻-新浪科技: 爱立信发布2013年第四季度及全年财报
- 科技要闻-新浪科技: 联想CFO:无需为收购摩托罗拉移动在债市融资
- Solidot: 利用盗链建立视频网站的创建者被判入狱半年
- Solidot: Edward Snowden被提名为诺贝尔和平奖候选人
- 科技要闻-新浪科技: 除夕微米再升级 借“活动”让社交走向线下
- 科技要闻-新浪科技: 沈阳:大量群发短信及内容涉黄赌毒手机可被锁
- 科技要闻-新浪科技: 美媒:阿里巴巴并非增长缓慢 马云另有安排
- 科技要闻-新浪科技: 联想集团港股早盘大跌7%
- 网易科技频道IT业界新闻: 杨元庆:对moto心仪很久 最后闪婚
- 网易科技频道IT业界新闻: 为何联想只卖了摩托2000个专利
- 网易科技频道IT业界新闻: Moto移动是给刘军的大礼,也是大考验
- Solidot: 联想29亿美元收购摩托罗拉移动,不包括专利
- 科技要闻-新浪科技: 巨屏新旗舰 诺基亚Lumia 1820 MWC发布
- 科技要闻-新浪科技: 新增2项专利 iPhone相机或支持更换镜头
- 科技要闻-新浪科技: iOS 7.0.5发布 修正国行版网络配置
- 网易科技频道IT业界新闻: 赛门铁克第三财季净利2.83亿美元 同比增长31%
- 网易科技频道IT业界新闻: 快讯:联想29亿美元收购摩托罗拉移动
- Latest Science News -- ScienceDaily: Digital test ...
- Latest Science News -- ScienceDaily: Running may b...
- Latest Science News -- ScienceDaily: Resetting, un...
- Solidot: 美国出口监管迫使Coursera拒绝来自古巴、伊朗、叙利亚和苏丹的学生
- 科技要闻-新浪科技: Evercore调降雅虎目标价和阿里估值
- 科技要闻-新浪科技: 盛大游戏成立特别委员会评估私有化要约
- Solidot: 中国富豪买不到Virgin Galactic的近太空旅游机票
- Solidot: 中国开发者推出马克思币
- Solidot: 硅谷企业的自满
- 网易科技频道IT业界新闻: 任天堂前三财季财报:净利润同比下跌30%
- Latest Science News -- ScienceDaily: Tropics are m...
- Latest Science News -- ScienceDaily: New NASA lase...
- Latest Science News -- ScienceDaily: 'Chameleon of...
- 科技要闻-新浪科技: 500彩票网宣布与中国移动子公司达成合作
- 科技要闻-新浪科技: 国美等获虚拟运营商牌照 将提供专属移动服务
- 科技要闻-新浪科技: 苏宁:冲刺中国最大虚拟运营商
- Solidot: 中国禽流感确诊病例达到110例,可能存在有限的人传人能力
- Solidot: 盖茨亲自遴选微软下一任CEO
- 科技要闻-新浪科技: 中芯国际2月18日发布第四季度财报
- 科技要闻-新浪科技: 美国运营商AT&T公布第四季度财报:同比扭亏
- 科技要闻-新浪科技: 伊坎称抛售股票者误读苹果财报
- Solidot: NSA利用手机应用数据挖掘情报
- Solidot: 五大国有银行被迫加息应对余额宝
- 网易科技频道IT业界新闻: 北京购纯电动车者最高补贴10.8万 特斯拉不在列
- 科技要闻-新浪科技: 传闻所谓诺基亚安卓手机实为双卡WP8手机
- 科技要闻-新浪科技: 富士X-T1发布会真机图赏 3款三防镜头亮相
- 科技要闻-新浪科技: 去年Q3全球互联网网速增长29%至3.6Mbps
- 网易科技频道IT业界新闻: 谷歌宣布与眼科保健商VSP Global合作
- 科技要闻-新浪科技: 或为最广全幅超广头 佳能11-24mm专利公开
- 科技要闻-新浪科技: 双卡双待金属手机 HTC 802d行货售2898
- 科技要闻-新浪科技: 松下将于2月7日发布4K微单 售价约2000美元
- 科技要闻-新浪科技: 揪出隐形杀手 五招教你消灭家电噪音
- 科技要闻-新浪科技: 五彩缤纷迎除夕 绚烂时尚液晶推荐
- 科技要闻-新浪科技: 买得起才是硬道理 工薪族购空调首选机型
- 网易科技频道IT业界新闻: 雅虎第四季度运营利润1.74亿美元 同比下滑8%
- 网易科技频道IT业界新闻: IBM拟出售SDN业务报价10亿美元
- 网易科技频道IT业界新闻: 激进投资人伊坎周二再增持5亿美元苹果股票
- 网易科技频道IT业界新闻: 黑莓发布10.2.1版黑莓10系统更新
- 网易科技频道IT业界新闻: 艺电第三财季净亏3.08亿美元 同比扩大
- 网易科技频道IT业界新闻: 传亚马逊年内发布低于300美元的Android游戏机
- 科技要闻-新浪科技: 自拍神器节前促销 卡西欧TR350售6399
- 科技要闻-新浪科技: 全新升级体验 索尼RX100II相机仅3750
- 科技要闻-新浪科技: 2230万像素全画幅 佳能5D3套机21300元
- 网易科技频道IT业界新闻: 苹果首季业绩稍逊预期:iPhone销量创纪录
- Latest Science News -- ScienceDaily: Parenting pla...
- Latest Science News -- ScienceDaily: Study shows v...
- Latest Science News -- ScienceDaily: Measuring wai...
- 科技要闻-新浪科技: 北京电信开通国际双号服务 易信用户可免费体验
- Latest Science News -- ScienceDaily: Don't judge o...
-
▼
一月
(1236)
没有评论:
发表评论